CFS gave the best response to those therapies with drug treatments having no benefit.
The condition's symptoms include headaches, poor sleep and joint and muscle pain. It is not contagious and but may have viral infection, stress and toxins as triggers.
For the study, Duncan Chambers and colleagues at the University of York studied 70 individual CFS cases.
Cognitive behavioral and exercise therapies were shown to decrease symptoms and amend physical function in CFS adult patients.
On the other hand, pharmacological treatments like antidepressants had no benefit.
Andrew Dillon, chief executive of the National Institute for Health and Clinical Excellence (NICE) , said: "CFS can cause prolonged illness and disability, which has a substantial impact on patients and their families.
"Uncertainties about diagnosis and management, and a lack of clinical guidance for healthcare professionals has exacerbated this impact.
"A national best practice guideline from NICE will help those working in the NHS to provide effective support, and we look forward to hearing the views of patients, carers, families and healthcare professionals during consultation."
