Nearly 75-percent of study participants experienced improvement in ADHD symptoms, according to preliminary results of the Quality of Life, Effectiveness, Safety, and Tolerability (Qu.E.S.T.) study, presented at the annual meeting of Children and Adults with Attention-Deficit/Hyperactivity Disorder (CHADD).
"Qu.E.S.T. is the largest study of its kind to date to document improvements in symptoms of adult ADHD," says Qu.E.S.T. investigator David Goodman, M.D., Director, Adult Attention Deficit Disorder Center of Maryland, Lutherville, Md. "The good news for adults with ADHD is that Adderall XR was shown to improve ADHD symptoms and was also generally well tolerated."
Qu.E.S.T. is a 30-week, open-label, multicenter investigation of adults, aged 18 and older, diagnosed with ADHD who receive treatment with once-daily Adderall XR, dosed at 10 mg to 60 mg daily.
During the 10-week study period, investigators gave patients 20 mg once- daily doses of Adderall XR during the first week. Based on the investigators' judgment, they adjusted doses to achieve optimal therapeutic response and tolerability in increments of 10 mg per day to a maximum dose of 60 mg daily. In adults with ADHD, the recommended dose is 20 mg per day.
