High alert has been declared in Pakistan after bird flu was confirmed in the country's port city, Karachi.

All the hospitals have been issued the directives in this connection and isolation wards have been set up at hospitals, The News, a local newspaper, reported quoting the health ministry.

A program worth $18.89 million (Rs1.18 billion) in this connection has been initiated.

No bird flu virus is found in the flesh of poultry, according to local reports quoting sources that added that culling the birds is incumbent upon the district government and the district government should manage the affairs including sanitation and spray.

Hundreds of birds at a poultry farm in the Gadap area of the port city were culled on Friday following confirmation of reports of an outbreak of bird flu. Personnel of the poultry and livestock and agriculture departments of the provincial and city governments killed the birds and buried them in a dry well in a farm on the instructions of Sindh Poultry Director Dr. Ali Akbar Soomro.

The H5N1 virus has been circulating in Asia since 1997 and it first appeared in Pakistan around two years ago.