Mohamed Idris, from Baheira, had been at a hospital in Egypt's second largest city Alexandria with reported respiratory problems and a high fever. He did not respond to the anti-viral drug Tamiflu, Deputy Minister Nasr Al Sayed told the official government news agency MENA.
He becomes Egypt's 48th case of a human infection from bird flu. The virus has devastated poultry populations worldwide.
Egypt is the worst hit nation outside East Asia, where the virus originated, due to its proximity to the convergence of three continents and the migration path for many birds.
The majority of those infected in Egypt have not followed the health ministry's regulations not to raise poultry in homes
